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DEVELOPMENT OF AN ASSAY FOR DIETARY AND EXPOSOME MEASUREMENTS FOR PRECISION MEDICINE

David S. Wishart

Abstract

Precision medicine is an emerging field of healthcare that uses multi-omics techniques (genomics, proteomics, transcriptomics, metabolomics) to precisely diagnose, monitor and treat individuals. The promise of precision medicine is that it will allow physicians to more precisely diagnose, treat or prevent disease. In this presentation I will try to make the case that precision medicine offers some of the best opportunities for metabolomics to successfully move out from the lab and into the clinic. I will also describe some of our laboratory’s efforts in using metabolomics for several “real world” precision medicine applications. These include the development of metabolic disorder screening assays, the creation of software tools to help integrate quantitative metabolomics with other omics data as well as the development of graphical interfaces to facilitate the clinical interpretation and visualization of multi-omics data for disease detection and wellness monitoring. Through our interactions with both patients and phyisicans we also discovered that there were several shortcomings with our initial approach to metabolite analysis. This led to the development of a number of new, lower-cost and higher throughput metabolomic assays that could facilitate improved diagnosis and patient monitoring. One of these includes a quantitative MS-based dietary and exoposome measurements.




DOI: http://dx.doi.org/10.14748/ssp.v4i1.3934

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David S. Wishart

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