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Annual for Hospital Pharmacy

Cost-effectiveness analysis of the health technologies for treatment of chronic lymphocytic leukemia

Toni Vekov, Slaveyko Djambazov

Abstract

Presented are analysis and assessment of target health technologies (antibodies and kinase inhibitors) used to treat chronic lymphocytic leukemia in Bulgaria during 2016. The aim of the study is to create pharmacotherapeutic guidelines for the treatment of CLL, based on clinical data for comparative therapeutic efficacy and economic data for comparative cost-effectiveness of possible therapeutic alternatives (comparators). We perform a systematic review of published data from health technology assessment for the treatment of CLL in MEDLINE, EMBASE, Web of Science, Cochrane Library for the period January 2005-June 2016 data for health benefits in terms of additional QALY, are directly transferred from other countries. Data on the cost of medicines therapies are based on local reference prices in Bulgaria available in the positive drug list to July 2016. The analysis of economic data and health technology assessment in Bulgaria for the treatment of chronic lymphocytic leukemia recommended RIT in combination with FLU and CYC as a possible efficient and cost-effective first-line therapy in patients with CLL and second line therapy in patients with relapsing or refractory CLL. In patients with CLL and deletion 17B or TP53 mutation recommended as first line therapeutic combination therapy both IDE and RIT.

Keywords

chronic lymphocytic leukemia; antibodies; kinase inhibitors; pharmacoeconomic evaluations; therapeutic alternatives; cost-effectiveness

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